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A 2025 analysis of FDA Adverse Event Reporting System data covering 81,078 GLP-1 receptor agonist reports found that compounded products were associated with higher reporting odds for several outcomes compared with FDA-approved versions: 2.8-fold for abdominal pain, 1.6-fold for diarrhea, 6.3-fold for suicidality, and 3.4-fold for cholecystitis